PI-115 - THE MATERNAL AND PEDIATRIC PRECISION IN THERAPEUTIC (MPRINT) KNOWLEDGEBASE PORTAL: A POWERFUL INFRASTRUCTURE FOR MATERNAL AND PEDIATRIC PRECISION THERAPEUTICS RESEARCH

L. Wang¹, A. Shendre², X. Liu¹, A. Goodwin³, S. Oteng³, J. Deypalubos³, S. Zhang³, S. Quinney^4,5, L. Li⁶; ¹The Ohio State University, Columbus, OH, USA, ²The Ohio State University, Columbus, USA, ³Ohio State University, Columbus, OH, United States, ⁴Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA, ⁵Department of OB/GYN, Indiana University School of Medicine, Indianapolis, IN, USA, ⁶The Ohio State University, Columbus, OH, United States.

Background: Maternal and pediatric groups have been underrepresented in clinical studies, leading to limited knowledge about drugs in these populations. The MPRINT knowledgebase portals integrates various maternal and pediatric physiology and pharmacology data from in vitro studies through clinical trials, supporting translational research in precision therapeutics in maternal and pediatric populations.

Methods: Four stages were involved – (1) Ontology development. The previously developed ontologies were expanded for maternal and pediatric populations. (2) Publication classification. Large language models and active learning methods were used to identify the study types (pharmacokinetics (PK), pharmacoepidemiology (PE), and clinical trials) and specific populations of publications (3) Knowledge curation. (4) Portal development. A relational database was developed to integrate various data resources. Users can use the web application to search the database through a Knowledgebase Portal on the MPRINT Hub website (mprint.org).

Results: The MPRINT Knowledgebase Portal is available in two versions, each designed for different purposes. The Silver version serves as a robust tool for discovering relevant maternal and pediatric publications. Users can search for publications using generic drug or chemical names, combined with demographic and disease information. A deep learning-based publication classification method demonstrated excellent performance, achieving F1 scores of 0.96, 0.98, and 0.96 for PK, clinical trials, and PE, respectively. The Silver version currently includes 758,560 abstracts (314,693 maternal and 670,185 pediatric publications) covering a total of 5,062 drugs and supplements. The Gold version provides curated and detailed knowledge, including PK parameters, clinical outcomes, risk factors, and adverse events for 255 drugs in maternal and pediatric populations, based on 2,573 publications. The accompanying table summarizes the current knowledge available in the MPRINT Knowledgebase Portal.

Conclusion: The MPRINT knowledgebase portal serves as a powerful infrastructure for facilitating research in maternal and pediatric precision therapeutics by integrating and assessing existing knowledge.