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Membrane Transporter (MT)

Membrane Transporter (MT)

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PI-022 - A CRISPR/CAS9-DERIVED ABCB1/ABCG2 KNOCKOUT PLATFORM FOR SUBSTRATE CHARACTERIZATION.

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PI-023 - INCORPORATING HEPATIC TRANSPORTER ZONATION INTO PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS: IMPLICATIONS FOR PRAVASTATIN DISPOSITION IN WHITE AND CHINESE POPULATIONS CONSIDERING OATP1B1 PHENOTYPES.

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PI-024 - PROMISING CAPACITY OF MACHINE LEARNING MODELS TO PREDICT OATP1B1- AND OATP1B3-MEDIATED INHIBITION POTENTIAL IN EARLY DRUG DISCOVERY.

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PT-004 - INTEGRATING BIOMARKERS AND PBPK MODELING TO UNCOVER THE MECHANISM OF A MULTI-TRANSPORTER DDI.

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PII-022 - CLINICAL DRUG-DRUG INTERACTION STUDIES INVESTIGATING THE EFFECT OF BAY 2927088 ON P-GP AND BCRP USING DABIGATRAN ETEXILATE AND ROSUVASTATIN

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PII-023 - PBPK MODEL DEVELOPMENT AND VALIDATION FOR ROSUVASTATIN: INTEGRATING IN VITRO, CLINICAL PHARMACOKINETIC, AND LIVER PET IMAGING DATA TO IMPROVE PREDICTIONS OF OATP1B- AND BCRP-MEDIATED DRUG-DRUG INTERACTIONS

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E-002 - REDUCTION IN ESTIMATED GLOMERULAR FILTRATION RATE (EGFR) OBSERVED WITH DORAVIRINE (DOR) IS CAUSED BY INHIBITION OF ORGANIC CATION TRANSPORTER 2 (OCT2)

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PWII-003 - INTEGRATING BIOMARKERS AND PBPK MODELING TO UNCOVER THE MECHANISM OF A MULTI-TRANSPORTER DDI.

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